Serum Free Light Chain
This test detects the present of serum immunoglobulin kappa and lambda free light chains, and expresses these as a ratio, the sFLC ratio.
| Tube | Serum Gel |
|---|---|
| ID | 12811 |
| Availability | Weekdays |
| Additional Information | Measurement of the kappa:lambda ratio provides a numerical indicator of clonality (Tumours produce monoclonal excess of only one of the light chain types, often with bone marrow suppression of the alternative light chain, so that the kappa:lambda ratios becomes skewed). A patient with a 'kappa' paraprotein (eg IgG Kappa, Kappa LCMM) will have an increased serum free ligh chain kappa:lambda ratio. A patient with a 'lambda' paraprotein with have a decreased serum free light chain kappa:lambda ratio. |
| Turn Around | 7 days |
| Send to | Leeds General Infirmary Clinical Immunology Old Medical School Great George Street Leeds LS1 3EX |
| Collection Con | No restrictions |
| Frequency | Daily |
| Sample REQ | Blood |
| Ref. Range (Male) | As set by Siemens N latext sFLC assay: Free kappa: 6.7-22.4 Free Lambda: 8.3-27 Kappa:Lambda Ratio: 0.31 - 1.56 |
| Ref. Range (Female) | As set by Siemens N latext sFLC assay: Free kappa: 6.7-22.4 Free Lambda: 8.3-27 Kappa:Lambda Ratio: 0.31 - 1.56 |
| Ref. Range (Paed) | As set by Siemens N latext sFLC assay: Free kappa: 6.7-22.4 Free Lambda: 8.3-27 Kappa:Lambda Ratio: 0.31 - 1.56 |
| Ref. Range Notes | (The sFLC kappa:lambda ratio in patients with renal failure do not differ from the reference limits for healthy controls) |
| Units | mg/L |
| IP Acute TAT | - Contact Laboratory |
| IP Routine TAT | 7 days |
| GP Acute TAT | - Contact Laboratory |
| GP Routine TAT | 7 days |
| Telepath | SFLC1L |
| ICE Codes | ISFLC |
