Heparin Induced Thrombocytopaenia (HIT) Screen
Heparin Induced Thrombocytopenia (HIT) is the development of a thrombocytopenia in patients on heparin therapy. This is an immune mediated disorder in which heparin binds to Platelet Factor 4. These antibodies can bind to the Fc receptor on platelets leading to platelet activation.
| Tube | 05 (CP) - Citrate |
|---|---|
| ID | 12734 |
| Availability | Daily (available Routine Hours). If required urgently out of routine working hours, please contact the on-call Haematology Consultant for the Haemophilia Network. |
| Additional Information | This test should only be requested after prior discussion with the haematology medical team. This HIT screen acts as a negative predictive indicator for the presence of HIT. A serum sample is required so any positive results can automatically be referred on to Royal Hallamshire Hospital, Sheffield (for confirmation by specific IgG antibody analysis) without having to recall the patient for re-bleeding. |
| Send to | Specialist Coagulation Chancellor / Lincoln Wing Link Corridor Pathology Block 32 St James University Hospital Beckett Street Leeds LS9 7TF |
| Contact | https://www.leedsth.nhs.uk/a-z-of-services/pathology-2/specialist-laboratory-medicine-slm/specialist-coagulation/?stage=Stage |
| Collection Con | 1x Citrate tube (Blue) filled to line AND 1 x Serum Gel (Gold) sample. Samples must be processed within 6 hours of being taken. |
| Sample REQ | Blood |
| Ref. Range (Male) | < 1.0 |
| Ref. Range (Female) | < 1.0 |
| Ref. Range (Paed) | < 1.0 |
| Ref. Range Notes | Critical telephone values: All results will be phoned to the coagulation registrar or haematology registrar on call (out of hours) |
| Units | U/mL |
| IP Acute TAT | Contact Laboratory |
| IP Routine TAT | 24 hours |
| GP Acute TAT | Contact Laboratory |
| GP Routine TAT | 24 hours |
| Telepath | HIT1J |
| ICE Codes | LHIT, SERUM |
